methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate

Base Information

Chemical Name:methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate
CAS No.:1374138-30-3
Molecular Formula:C₃₄H₄₅F₂N₃O₉
Molecular Weight:677.743
Hs Code.:

Synonyms:methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate

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Chemical Property of methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate

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Technology Process of methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate

There total 8 articles about methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374138-29-0
methyl N₂,N₂-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate

: 161869-03-0
(S)-2-((methoxycarbonyl)amino)-3,3-diphenylpropanoic acid

: 1374138-30-3
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 157701-42-3
(S)-dimethyl 2-aminohexanedioate hydrochloride

: 1374138-30-3
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / dichloromethane / 20 °C

2.1: diisobutylaluminium hydride / diethyl ether; hexanes / 1.5 h / -78 - -70 °C

2.2: 0.67 h / 20 °C

3.1: N-fluorobis(benzenesulfon)imide; rac-Pro-OH / isopropyl alcohol; tetrahydrofuran / 24 h / 0 - 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -40 - 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 50 °C

6.1: toluene-4-sulfonic acid; zinc; ammonium chloride / N,N-dimethyl-formamide / 2.17 h / 20 °C

7.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With sodium azide; diisobutylaluminium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; toluene-4-sulfonic acid; N-fluorobis(benzenesulfon)imide; triethylamine; N-ethyl-N,N-diisopropylamine; rac-Pro-OH; zinc; dmap; In tetrahydrofuran; hexanes; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: (2S)-2-amino-6-methoxy-6-oxo-hexanoic acid

: 1374138-30-3
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2,N2-bis(tert-butoxycarbonyl)-5,5-difluoro-L-lysinate

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 12 - 20 °C

2.1: dmap / dichloromethane / 20 °C

3.1: diisobutylaluminium hydride / diethyl ether; hexanes / 1.5 h / -78 - -70 °C

3.2: 0.67 h / 20 °C

4.1: N-fluorobis(benzenesulfon)imide; rac-Pro-OH / isopropyl alcohol; tetrahydrofuran / 24 h / 0 - 20 °C

4.2: 1.5 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -40 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 3 h / 50 °C

7.1: toluene-4-sulfonic acid; zinc; ammonium chloride / N,N-dimethyl-formamide / 2.17 h / 20 °C

8.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With thionyl chloride; sodium azide; diisobutylaluminium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; toluene-4-sulfonic acid; N-fluorobis(benzenesulfon)imide; triethylamine; N-ethyl-N,N-diisopropylamine; rac-Pro-OH; zinc; dmap; In tetrahydrofuran; hexanes; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;