ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate

Base Information

Chemical Name:ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate
CAS No.:347174-07-6
Molecular Formula:C₃₀H₃₁BrN₂O₄
Molecular Weight:563.491
Hs Code.:

Synonyms:ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate

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Chemical Property of ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate

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Technology Process of ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate

There total 3 articles about ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 347165-36-0
ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)-1H-benzimidazole-5-carboxylate

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 347174-07-6
ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2.5h;
DOI:10.1021/jm060269e

Reference yield:

: 150192-39-5
2-Bromo-5-methoxybenzyl alcohol

: 347174-07-6
ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / CBr₄; PPh₃ / tetrahydrofuran / 1 h / 20 °C

2: K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

With carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm060269e

Reference yield:

: 22921-68-2
2-bromo-5-methoxy-benzoic acid

: 347174-07-6
ethyl 2-[4-(2-bromo-5-methoxybenzyloxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

2: 55 percent / CBr₄; PPh₃ / tetrahydrofuran / 1 h / 20 °C

3: K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

With lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm060269e