(R)-2-(3-Chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetic acid

Base Information

Chemical Name:(R)-2-(3-Chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetic acid
CAS No.:853782-50-0
Molecular Formula:C₉H₇ClF₂O₄
Molecular Weight:252.602
Hs Code.:
European Community (EC) Number:617-706-5
DSSTox Substance ID:DTXSID401181328

Synonyms:(R)-2-(3-Chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetic acid;SCHEMBL12588358;OYYVYWAGOSRCCZ-ZETCQYMHSA-N;DTXSID401181328;(alphaS)-3-Chloro-5-(difluoromethoxy)-alpha-hydroxybenzeneacetic acid;853782-50-0

Suppliers and Price of (R)-2-(3-Chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (R)-2-(3-Chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetic acid

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:252.0000927
Heavy Atom Count:16
Complexity:252

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C=C(C=C1OC(F)F)Cl)C(C(=O)O)O
Isomeric SMILES:C1=C(C=C(C=C1OC(F)F)Cl)[C@@H](C(=O)O)O

Technology Process of (R)-2-(3-Chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetic acid

There total 3 articles about (R)-2-(3-Chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-chloro-5-difluoro-methoxy-mandelic acid D-prolinamide salt

: 853782-50-0
(S)-3-chloro-5-difluoro-methoxy-mandelic acid

Guidance literature:: 3-chloro-5-difluoro-methoxy-mandelic acid D-prolinamide salt; With hydrogenchloride; water; In ethyl acetate; at 15 - 25 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate; Product distribution / selectivity;

Reference yield:

: 433938-41-1
Ph(3-Cl)(5-OCHF₂)-(R,S)CH(OH)C(O)OH

: 7531-52-4
L-prolinamide

: 853782-50-0
(S)-3-chloro-5-difluoro-methoxy-mandelic acid

Guidance literature:: Ph(3-Cl)(5-OCHF₂)-(R,S)CH(OH)C(O)OH; L-prolinamide; In 1,4-dioxane; at 90 ℃; Resolution of racemate;

With hydrogenchloride; In water; ethyl acetate; Purification / work up; Resolution of racemate;