(S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol

Base Information

• Chemical Name: (S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol
• CAS No.: 104324-70-1
• Molecular Formula: C₂₃H₄₁NO₅Si₂
• Molecular Weight: 467.753
• Mol file: 104324-70-1.mol

Synonyms:(S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol

Chemical Property of (S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol

There total 1 articles about (S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3:4,5-di-O-isopropylidene-aldehydo-D-ribose (50866-82-5) + lithium → (S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol (104324-70-1)

Guidance literature:

In diethyl ether; at -78 ℃; for 12h;

DOI:10.1021/ja00280a077

Reference yield:

(S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol (104324-70-1) → Trifluoro-acetic acid (1S,2S)-3-(4-amino-phenyl)-1-[(R)-1,2-bis-(2,2,2-trifluoro-acetoxy)-ethyl]-2-(2,2,2-trifluoro-acetoxy)-propyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LiAlH₄, 2.) 1 M HCl / 1.) ether, 80 deg C, 48 h., 2.) 1 h., 100 deg C

2: CH₂Cl₂ / 2 h / 60 °C

With hydrogenchloride; lithium aluminium tetrahydride; In dichloromethane;

DOI:10.1021/ja00280a077

Reference yield:

(S)-[4-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methanol (104324-70-1) → 1-(4-aminophenyl)-1-deoxy-D-ribitol (104418-83-9)

Guidance literature:

With hydrogenchloride; lithium aluminium tetrahydride; Multistep reaction; 1.) ether, 80 deg C, 48 h., 2.) 1 h., 100 deg C;

DOI:10.1021/ja00280a077

upstream raw materials:

2,3:4,5-di-O-isopropylidene-aldehydo-D-ribose

Downstream raw materials:

1-(4-aminophenyl)-1-deoxy-D-ribitol