N⁶-{[4-(tert-butyl)phenoxy]acetyl}-2'-deoxy-3'-O-{[2-(2-nitrophenyl)propoxy]carbonyl}adenosine

Base Information

• Chemical Name: N⁶-{[4-(tert-butyl)phenoxy]acetyl}-2'-deoxy-3'-O-{[2-(2-nitrophenyl)propoxy]carbonyl}adenosine
• CAS No.: 298699-73-7
• Molecular Formula: C₃₂H₃₆N₆O₉
• Molecular Weight: 648.673

Synonyms:N⁶-{[4-(tert-butyl)phenoxy]acetyl}-2'-deoxy-3'-O-{[2-(2-nitrophenyl)propoxy]carbonyl}adenosine

Chemical Property of N⁶-{[4-(tert-butyl)phenoxy]acetyl}-2'-deoxy-3'-O-{[2-(2-nitrophenyl)propoxy]carbonyl}adenosine

Chemical Property:

Purity/Quality:

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Technology Process of N⁶-{[4-(tert-butyl)phenoxy]acetyl}-2'-deoxy-3'-O-{[2-(2-nitrophenyl)propoxy]carbonyl}adenosine

There total 2 articles about N⁶-{[4-(tert-butyl)phenoxy]acetyl}-2'-deoxy-3'-O-{[2-(2-nitrophenyl)propoxy]carbonyl}adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-{[2-(2-nitrophenyl)propoxy]carbonyl}-1-methyl-1H-imidazolium chloride + N6-(4-i-propylphenoxy)acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine → N6-{[4-(tert-butyl)phenoxy]acetyl}-2'-deoxy-3'-O-{[2-(2-nitrophenyl)propoxy]carbonyl}adenosine (298699-73-7)

Guidance literature:

With 4 A molecular sieve; In dichloromethane; at 0 ℃;

DOI:10.1002/1522-2675(20010711)84:7<2089::AID-HLCA2089>3.0.CO;2-0

Reference yield:

2-(2-nitrophenyl)propyl carbonochloridate (154187-40-3) → N6-{[4-(tert-butyl)phenoxy]acetyl}-2'-deoxy-3'-O-{[2-(2-nitrophenyl)propoxy]carbonyl}adenosine (298699-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 Angstroem mol. sieves / CH₂Cl₂ / 0.5 h / 0 °C

2: 86 percent / 4 Angstroem mol. sieves / CH₂Cl₂ / 0 °C

With 4 A molecular sieve; In dichloromethane;

DOI:10.1002/1522-2675(20010711)84:7<2089::AID-HLCA2089>3.0.CO;2-0

upstream raw materials:

2-(2-nitrophenyl)propyl carbonochloridate

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