1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Base Information

• Chemical Name: 1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide
• CAS No.: 945267-49-2
• Molecular Formula: C₂₃H₂₅N₃O₂
• Molecular Weight: 375.47
• Mol file: 945267-49-2.mol

Synonyms:1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Chemical Property of 1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

There total 2 articles about 1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-propionylamino-cyclopentanecarboxylic acid (945267-43-6) + [(2'-cyanobiphenyl-4-yl)methyl]amine (133690-92-3) → 1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (945267-49-2)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 25 - 35 ℃;

DOI:10.1515/HC.2006.12.5.323

Reference yield:

1-amino-1-cyclopentanecarboxylic acid (52-52-8) → 1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (945267-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / sodium hydroxide / H₂O; toluene / 2 h / 0 - 10 °C

2: 92 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH₂Cl₂ / 25 - 35 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; water; toluene;

DOI:10.1515/HC.2006.12.5.323

Reference yield: 78.0%

1-propionylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (945267-49-2) → 4'-(2-ethyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)biphenyl-2-carbonitrile (235431-62-6)

Guidance literature:

With trifluoroacetic acid; In toluene; Heating;

DOI:10.1515/HC.2006.12.5.323

upstream raw materials:

1-propionylamino-cyclopentanecarboxylic acid

[(2'-cyanobiphenyl-4-yl)methyl]amine

1-amino-1-cyclopentanecarboxylic acid

Downstream raw materials:

4'-(2-ethyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)biphenyl-2-carbonitrile