5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Base Information

Chemical Name:5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
CAS No.:713517-50-1
Molecular Formula:C₂₃H₁₉ClN₂O₂
Molecular Weight:390.869
Hs Code.:

5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[<i>e</i>][1,4]diazepin-2-one

Synonyms:5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Chemical Property of 5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Technology Process of 5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

There total 5 articles about 5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 824-94-2
p-methoxybenzyl chloride

: 713517-49-8
5-(3-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 713517-50-1
5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm031115r

Reference yield:

: 108-37-2
1-bromo-3-chlorobenzene

: 713517-50-1
5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: Mg / diethyl ether / Heating

1.2: diethyl ether / Heating

1.3: aq. HCl / diethyl ether

2.1: CH₂Cl₂; H₂O / 20 °C

3.1: 12.8 g / NH₃ / methanol / 45 °C

4.1: 86 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

With ammonia; potassium carbonate; magnesium; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm031115r

Reference yield:

: 57479-65-9
2-amino-3'-chlorobenzophenone

: 713517-50-1
5-(3-chloro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂; H₂O / 20 °C

2: 12.8 g / NH₃ / methanol / 45 °C

3: 86 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

With ammonia; potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm031115r