(S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one

Base Information

Chemical Name:(S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one
CAS No.:1201518-30-0
Molecular Formula:C₂₅H₃₂N₂O₅
Molecular Weight:440.539
Hs Code.:

Synonyms:(S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one

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Chemical Property of (S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one

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Technology Process of (S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one

There total 6 articles about (S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.6%

: 478912-40-2
(4S)-3-(2-methylene-1-oxohexyl)-4-(phenylmethyl)-2-oxazolidinone

: 51307-59-6
N-(4-methoxybenzyl)hydroxylamine

: 1201518-30-0
(S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one

Guidance literature:: (4S)-3-(2-methylene-1-oxohexyl)-4-(phenylmethyl)-2-oxazolidinone; N-(4-methoxybenzyl)hydroxylamine; at 45 ℃; for 24h; Inert atmosphere;

With toluene-4-sulfonic acid; In ethyl acetate; for 1.5h; Inert atmosphere;

With sodium carbonate; In water; ethyl acetate; for 0.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.07.106

Reference yield: 58.0%

: 478912-40-2
(4S)-3-(2-methylene-1-oxohexyl)-4-(phenylmethyl)-2-oxazolidinone

: 21038-22-2
O-(4-methoxybenzyl)hydroxylamine

: 1201518-30-0
(S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one

Guidance literature:: at 50 ℃; for 24h; diastereoselective reaction;
DOI:10.1016/j.bmcl.2010.04.123

Reference yield:

: C₁₂H₂₀O₃

: 1201518-30-0
(S)-3-((R)-2-((4-methoxybenzyloxyamino)methyl)hexanoyl)-4-benzyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: 24 h / 45 °C / Inert atmosphere

2.2: 1.5 h / Inert atmosphere

2.3: 0.5 h / Inert atmosphere

With n-butyllithium; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2014.07.106