4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

Base Information

Chemical Name:4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole
CAS No.:290353-19-4
Molecular Formula:C₂₅H₂₄IN₃O
Molecular Weight:509.39
Hs Code.:

Synonyms:4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

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Chemical Property of 4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

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Technology Process of 4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

There total 10 articles about 4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 291537-04-7
5-(N,N-diethylamino)-2-[4-(2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzenesulfonate

: 290353-19-4
4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;
DOI:10.1016/S0040-4039(00)00621-3

Reference yield:

: 17754-90-4
4-(Diethylamino)salicylaldehyde

: 290353-19-4
4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: 52 percent / K₂CO₃ / acetone / 2 h / 20 °C

2.1: 84 percent / H₂O; acetonitrile / 20 °C

3.1: NaH / dimethylformamide / -19 °C

3.2: dimethylformamide / -19 - 20 °C

4.1: 54 percent / conc. HCl / methanol; H₂O / 90 °C

5.1: 58 percent / toluene / 90 °C

6.1: 91 percent / Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

7.1: 64 percent / t-BuOK / dimethylformamide / 0 °C

With hydrogenchloride; potassium tert-butylate; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; In methanol; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 5.1: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j

Reference yield:

: 59-88-1
phenylhydrazine hydrochloride

: 290353-19-4
4-(5-N,N-diethylamino-2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

2: 64 percent / t-BuOK / dimethylformamide / 0 °C

With potassium tert-butylate; sodium carbonate; acetic acid; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo025767j