C₃₃H₂₅N₃O₄

Base Information

• Chemical Name: C₃₃H₂₅N₃O₄
• CAS No.: 1376947-92-0
• Molecular Formula: C₃₃H₂₅N₃O₄
• Molecular Weight: 527.579
• Mol file: 1376947-92-0.mol

Synonyms:C₃₃H₂₅N₃O₄

Chemical Property of C₃₃H₂₅N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₂₅N₃O₄

There total 1 articles about C₃₃H₂₅N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-ethoxycarbonylphthalimide (22509-74-6) + trityl chloride (76-83-5) + L-histidine (71-00-1) → C33H25N3O4 (1376947-92-0)

Guidance literature:

N-ethoxycarbonylphthalimide; L-histidine; With sodium carbonate; In water; for 3h;

trityl chloride; With triethylamine; In chloroform; N,N-dimethyl-formamide; at 0 - 20 ℃;

In methanol; chloroform; N,N-dimethyl-formamide; at 50 ℃; for 2h;

DOI:10.1016/j.tet.2011.11.066

Reference yield: 46.0%

C33H25N3O4 (1376947-92-0) → C33H27N3O3 (1376947-95-3)

Guidance literature:

With sodium tetrahydroborate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

DOI:10.1016/j.tet.2011.11.066

Reference yield:

C33H25N3O4 (1376947-92-0) → C33H26N6O2 (1376948-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 0 °C

2: triethylamine / dichloromethane / 0.33 h / 0 °C

3: sodium azide / N,N-dimethyl-formamide / 80 °C

With sodium tetrahydroborate; sodium azide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.11.066

upstream raw materials:

N-ethoxycarbonylphthalimide

trityl chloride

L-histidine

Downstream raw materials:

C₃₄H₂₉N₃O₅S

C₃₃H₂₆N₆O₂

C₃₃H₂₇N₃O₃