3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide

Base Information

• Chemical Name: 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide
• CAS No.: 80972-32-3
• Molecular Formula: C₂₄H₂₅N₃O₄S₂
• Molecular Weight: 483.612
• Mol file: 80972-32-3.mol

Synonyms:3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide

Chemical Property of 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide

There total 5 articles about 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-morpholin-4-yl-3-oxo-propyl]-amide (80972-18-5) → 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide (80972-32-3)

Guidance literature:

With TEA; hydrogen sulfide; In pyridine; for 30h; Ambient temperature;

Reference yield:

3-Cyanobenzaldehyde (24964-64-5) → 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide (80972-32-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 33 percent / CH₃COONH₄ / aq. ethanol / 4 h / Heating

2: 65 percent / KOH (1mol/l) / diethyl ether / 12 h / Ambient temperature

3: SOCl₂ / 1 h / Heating

4: 62 percent / benzene / Ambient temperature

5: 87 percent / H₂S(gas), TEA / pyridine / 30 h / Ambient temperature

With potassium hydroxide; thionyl chloride; TEA; hydrogen sulfide; ammonium acetate; In pyridine; diethyl ether; ethanol; benzene;

Reference yield:

β-(m-Cyanphenyl)-β-alanin (80971-96-6,761396-82-1,791778-00-2) → 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide (80972-32-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / KOH (1mol/l) / diethyl ether / 12 h / Ambient temperature

2: SOCl₂ / 1 h / Heating

3: 62 percent / benzene / Ambient temperature

4: 87 percent / H₂S(gas), TEA / pyridine / 30 h / Ambient temperature

With potassium hydroxide; thionyl chloride; TEA; hydrogen sulfide; In pyridine; diethyl ether; benzene;

upstream raw materials:

Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-morpholin-4-yl-3-oxo-propyl]-amide

3-Cyanobenzaldehyde

β-(m-Cyanphenyl)-β-alanin

3-(3-Cyano-phenyl)-3-(naphthalene-2-sulfonylamino)-propionic acid

Downstream raw materials:

3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine; hydriodide

3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzimidic acid methyl ester; hydriodide