5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxy-6-thioguanosine

Base Information

• Chemical Name: 5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxy-6-thioguanosine
• CAS No.: 125676-68-8
• Molecular Formula: C₃₅H₃₇N₅O₆S
• Molecular Weight: 655.775
• Mol file: 125676-68-8.mol

Synonyms:5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxy-6-thioguanosine

Chemical Property of 5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxy-6-thioguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxy-6-thioguanosine

There total 1 articles about 5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxy-6-thioguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-dimethoxytriphenylmethyl-N2-isobutyryl-2'-deoxyguanosine (68892-41-1) → 5'-dimethoxytriphenylmethyl-N2-isobutyryl-2'-deoxy-6-thioguanosine (125676-68-8)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4020(01)88731-7

Reference yield: 92.0%

2,4-Dinitrofluorobenzene (70-34-8,65727-75-5) + 5'-dimethoxytriphenylmethyl-N2-isobutyryl-2'-deoxy-6-thioguanosine (125676-68-8) → 5'-dimethoxytriphenylmethyl-N2-isobutyryl-2'-deoxy-6-(2,4-dinitrophenyl)thioguanosine (141076-13-3)

Guidance literature:

With triethylamine; In acetonitrile; for 0.666667h;

DOI:10.1016/S0040-4020(01)88731-7

Reference yield:

5'-dimethoxytriphenylmethyl-N2-isobutyryl-2'-deoxy-6-thioguanosine (125676-68-8) → 5'-dimethoxytriphenylmethyl-N2-isobutyryl-2'-deoxy-6-(2,4-dinitrophenyl)thioguanosine-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphite (141076-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N / acetonitrile / 0.67 h

2: 62.1 percent / N,N-diisopropylethyl amine / tetrahydrofuran / 1) 10 min., ice bath, 2) RT

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1016/S0040-4020(01)88731-7

upstream raw materials:

5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxyguanosine

Downstream raw materials:

5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxy-6-(2,4-dinitrophenyl)thioguanosine

5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxy-6-(2,4-dinitrophenyl)thioguanosine-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphite