13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

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Chemical Name:13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid
CAS No.:1127236-35-4
Molecular Formula:C₃₅H₃₈N₄O₅
Molecular Weight:594.711
Hs Code.:

Synonyms:13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

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Chemical Property of 13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

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Technology Process of 13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

There total 1 articles about 13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1127236-34-3
13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

: 1127236-35-4
13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 3h;

Reference yield: 61.0%

: 81363-76-0
propane-2-sulfonamide

: 1127236-35-4
13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

: 1127236-40-1
13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: 13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 1h;

propane-2-sulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 - 60 ℃; for 19h;

Reference yield: 51.0%

: 110-91-8,99108-56-2
morpholine

: 1127236-35-4
13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

: 1127236-36-5
4-[[13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepin-10-yl]carbonyl]-morpholine

Guidance literature:: 13-cyclohexyl-6-[1-ethyl-4-(morpholin-4-ylcarbonyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 1h;

morpholine; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; Heating / reflux;