6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride

Base Information

Chemical Name:6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride
CAS No.:81806-37-3
Molecular Formula:C₁₈H₂₇N₃O₄*ClH
Molecular Weight:385.891
Hs Code.:

Synonyms:6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride

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Chemical Property of 6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride

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Technology Process of 6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride

There total 7 articles about 6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 81806-37-3
6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / NaHCO₃ / dimethylformamide / 120 h / Ambient temperature

2: 98 percent / HCl / dioxane / 0.5 h / Ambient temperature

3: 85 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

4: HCl / dioxane / 0.5 h / Ambient temperature

5: 90 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

6: HCl / dioxane / 0.5 h / Ambient temperature

With hydrogenchloride; TEA; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 81806-35-1
Boc-Gly-Phe-εAhx-OMe

: 81806-37-3
6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 0.5h; Ambient temperature;

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 81806-37-3
6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

2: HCl / dioxane / 0.5 h / Ambient temperature

3: 90 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

4: HCl / dioxane / 0.5 h / Ambient temperature

With hydrogenchloride; TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;