(S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid

Base Information

Chemical Name:(S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid
CAS No.:1400660-70-9
Molecular Formula:C₂₂H₂₁N₃O₆S₂
Molecular Weight:487.557
Hs Code.:

Synonyms:(S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid

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Chemical Property of (S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid

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Technology Process of (S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid

There total 10 articles about (S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400662-96-5
C₂₃H₂₃N₃O₆S₂

: 1400660-70-9
(S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid

Guidance literature:: C₂₃H₂₃N₃O₆S₂; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 0.666667h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 873-62-1
m-cyanophenol

: 1400660-70-9
(S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 2585.81 Torr

3: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C

4: water; lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C

5: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

6: dichloromethane / 0.33 h / 20 °C

7: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C

8: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.67 h / 20 °C

With 1H-imidazole; lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 160833-27-2
3-(tert-butyldimethylsilyloxy)benzonitrile

: 1400660-70-9
(S)-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophen-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 2585.81 Torr

2: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C

3: water; lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C

4: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

5: dichloromethane / 0.33 h / 20 °C

6: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C

7: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.67 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;