N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Base Information

Chemical Name:N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
CAS No.:1314786-34-9
Molecular Formula:C₂₃H₁₈F₃N₇O
Molecular Weight:465.437
Hs Code.:

Synonyms:N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

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Chemical Property of N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

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Technology Process of N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

There total 4 articles about N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1185019-85-5
3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline

: 1314787-71-7
C₁₃H₇F₃IN₃

: 1314786-34-9
N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-butyl alcohol; at 110 ℃; for 20h; Inert atmosphere;

Reference yield:

: 454-16-0
1-fluoro-2-methoxy-4-nitrobenzene

: 1314786-34-9
N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

2: hydrogen; thiophene / palladium 10% on activated carbon / di-isopropyl ether; methanol / 25 °C

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With thiophene; hydrogen; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In methanol; di-isopropyl ether; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1185019-82-2
1-(2-methoxy-4-nitrophenyl)-3-methyl-1H-1,2,4-triazole

: 1314786-34-9
N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; thiophene / palladium 10% on activated carbon / di-isopropyl ether; methanol / 25 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With thiophene; hydrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In methanol; di-isopropyl ether; tert-butyl alcohol;