5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide

Base Information

Chemical Name:5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide
CAS No.:1415247-17-4
Molecular Formula:C₂₆H₃₂N₂O₄
Molecular Weight:436.551
Hs Code.:

Synonyms:5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide

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Chemical Property of 5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide

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Technology Process of 5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide

There total 2 articles about 5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1415247-19-6
5,6-dimethoxy-3-methyl-N-phenylbenzofuran-2-carboxamide

: 5472-49-1
1-(3-chloropropyl)piperidine hydrochloride

: 1415247-17-4
5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide

Guidance literature:: 5,6-dimethoxy-3-methyl-N-phenylbenzofuran-2-carboxamide; With sodium hydride; In dichloromethane; mineral oil; for 1h; Inert atmosphere; Reflux;

1-(3-chloropropyl)piperidine hydrochloride; With tetrabutylammomium bromide; potassium carbonate; potassium iodide; In dichloromethane; mineral oil; for 24h; Reflux;
DOI:10.1016/j.bmc.2012.09.044

Reference yield:

: 108761-23-5
5,6-dimethoxy-3-methyl-1-benzofuran-2-carboxylic acid

: 62-53-3
aniline

: 1415247-17-4
5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 23 h / 20 °C

2.1: sodium hydride / dichloromethane; mineral oil / 1 h / Inert atmosphere; Reflux

2.2: 24 h / Reflux

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In dichloromethane; mineral oil;
DOI:10.1016/j.bmc.2012.09.044