(-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine

Base Information

Chemical Name:(-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine
CAS No.:935683-82-2
Molecular Formula:C₂₂H₂₉F₂NOSi
Molecular Weight:389.561
Hs Code.:

Synonyms:(-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine

Chemical Property:

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Technology Process of (-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine

There total 7 articles about (-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 935683-81-1
(+)-4-azido-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentane

: 935683-82-2
(-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 2h; under 1551.49 Torr;
DOI:10.1021/jm061304k

Reference yield:

: 855662-67-8
(+)-(1R,2S,3S,4R)-1-O-benzyloxy-2,3-anhydro-4-hydroxymethylcyclopentane

: 935683-82-2
(-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / triethylamine; DMAP / CH₂Cl₂ / 24 h / 20 °C

2: 92 percent / Super-Hydride / tetrahydrofuran / 0.5 h / 20 °C

3: 81 percent / pyridinium dichromate; acetic acid; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 20 °C

4: 68 percent / diethylaminosulfur trifluoride / 36 h / 40 °C

5: 70 percent / iodotrimethylsilane / CH₂Cl₂ / 14 h / 20 °C

6: 74 percent / imidazole / CH₂Cl₂ / 1.75 h / 0 °C

7: 98 percent / triethylamine / CH₂Cl₂ / 4 h / 20 °C

8: 93 percent / NaN₃ / dimethylformamide / 1.5 h / 130 °C

9: 95 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C / 1551.49 Torr

With 1H-imidazole; dmap; dipyridinium dichromate; sodium azide; trimethylsilyl iodide; diethylamino-sulfur trifluoride; 4 A molecular sieve; hydrogen; lithium triethylborohydride; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm061304k

Reference yield:

: 935683-77-5
(+)-4-O-benzyloxy-1,1-difluoro-2-(O-triphenylmethyloxymethyl)-cyclopentane

: 935683-82-2
(-)-2-(O-tert-butyldiphenylsilyloxymethyl)-1,1-difluoro-cyclopentanamine

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / iodotrimethylsilane / CH₂Cl₂ / 14 h / 20 °C

2: 74 percent / imidazole / CH₂Cl₂ / 1.75 h / 0 °C

3: 98 percent / triethylamine / CH₂Cl₂ / 4 h / 20 °C

4: 93 percent / NaN₃ / dimethylformamide / 1.5 h / 130 °C

5: 95 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C / 1551.49 Torr

With 1H-imidazole; sodium azide; trimethylsilyl iodide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm061304k