4-[2-(3-Pyridinyl)ethenyl]phenol

Base Information

• Chemical Name: 4-[2-(3-Pyridinyl)ethenyl]phenol
• CAS No.: 20934-82-1
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.236
• DSSTox Substance ID: DTXSID701302832
• Mol file: 20934-82-1.mol

Synonyms:DTXSID701302832;4-[2-(3-Pyridinyl)ethenyl]phenol;20934-82-1

Chemical Property of 4-[2-(3-Pyridinyl)ethenyl]phenol

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 197.084063974
• Heavy Atom Count: 15
• Complexity: 207

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CN=C1)C=CC2=CC=C(C=C2)O

Technology Process of 4-[2-(3-Pyridinyl)ethenyl]phenol

There total 3 articles about 4-[2-(3-Pyridinyl)ethenyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triphenyl-(pyridin-3-yl-methyl)-phosphonium chloride (79296-92-7) → (E,Z)-1-(4-hydroxyphenyl)-2-(3-pyridyl)ethylene (20934-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / hexane / 0.5 h / Ambient temperature

2: tetrahydrofuran / Ambient temperature

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1021/jm00158a024

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + 3-(triphenyl-λ5-phosphanylidenemethyl)-pyridine (51432-67-8) → (E,Z)-1-(4-hydroxyphenyl)-2-(3-pyridyl)ethylene (20934-82-1)

Guidance literature:

In tetrahydrofuran; Yield given; Ambient temperature;

DOI:10.1021/jm00158a024

Reference yield:

→ (E,Z)-1-(4-hydroxyphenyl)-2-(3-pyridyl)ethylene (20934-82-1)

Guidance literature:

4'-Methoxy-stilbazol-3, BBr3, Ausb. 58percent;

upstream raw materials:

4-hydroxy-benzaldehyde

3-(triphenyl-λ⁵-phosphanylidenemethyl)-pyridine

triphenyl-(pyridin-3-yl-methyl)-phosphonium chloride

Downstream raw materials:

1-(4-hydroxyphenyl)-2-(3-pyridyl)ethane

1-(3-Hydroxyphenyl)-2-(3-pyridinyl)ethane

2-Hydroxy-4-[2-(3'-pyridinyl)ethyl]benzaldehyde

2-Hydroxy-5-(2-pyridin-3-yl-ethyl)-benzaldehyde