(3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester

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Chemical Name:(3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester
CAS No.:766553-17-7
Molecular Formula:C₃₆H₂₉ClN₄O₅S
Molecular Weight:665.169
Hs Code.:

(3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester

Synonyms:(3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester

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Chemical Property of (3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester

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Technology Process of (3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester

There total 10 articles about (3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 766556-94-9
(3S,4R)-3-azido-4-tert-butoxycarbonylamino-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

: 766553-17-7
(3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol

2: BOP; NMM / tetrahydrofuran

3: TFA / CH₂Cl₂

4: BOP; NMM / tetrahydrofuran

With 4-methyl-morpholine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.07.020

Reference yield:

: C₂₂H₂₆N₄O₃Si

: 766553-17-7
(3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / 10-CSA / methanol

2: 91 percent / H₂ / Pd/C / ethyl acetate

3: HN₃; DEAD; PPh₃ / tetrahydrofuran; toluene / -78 - 20 °C

4: H₂ / Pd/C / ethanol

5: BOP; NMM / tetrahydrofuran

6: TFA / CH₂Cl₂

7: BOP; NMM / tetrahydrofuran

With 4-methyl-morpholine; tris-(2-chloro-ethyl)-amine; (1S)-10-camphorsulfonic acid; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; toluene; 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2007.07.020

Reference yield:

: 766556-92-7
(3R,4R)-3-azido-4-hydroxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

: 766553-17-7
(3R,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / H₂ / Pd/C / ethyl acetate

2: HN₃; DEAD; PPh₃ / tetrahydrofuran; toluene / -78 - 20 °C

3: H₂ / Pd/C / ethanol

4: BOP; NMM / tetrahydrofuran

5: TFA / CH₂Cl₂

6: BOP; NMM / tetrahydrofuran

With 4-methyl-morpholine; tris-(2-chloro-ethyl)-amine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene; 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2007.07.020