4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile

Base Information

Chemical Name:4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile
CAS No.:1580001-68-8
Molecular Formula:C₂₁H₁₈IN₃O₂
Molecular Weight:471.297
Hs Code.:

Synonyms:4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile

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Chemical Property of 4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile

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Technology Process of 4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile

There total 7 articles about 4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1580052-86-3
4-((4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile

: 1580001-68-8
4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile

Guidance literature:: With N-iodo-succinimide; acetic acid; trifluoroacetic acid; at 20 ℃;
DOI:10.1016/j.bmc.2014.01.054

Reference yield:

: 1580002-02-3
2-chloro-4-(mesityloxy)-6-methoxypyridine

: 1580001-68-8
4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 100 °C / Schlenk technique; Inert atmosphere

2: chloro-trimethyl-silane; sodium iodide / acetonitrile / Reflux

3: N-iodo-succinimide; acetic acid; trifluoroacetic acid / 20 °C

With N-iodo-succinimide; chloro-trimethyl-silane; palladium diacetate; acetic acid; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium iodide; sodium t-butanolate; In 1,4-dioxane; acetonitrile;
DOI:10.1016/j.bmc.2014.01.054

Reference yield:

: 1580002-10-3
4-((4-(mesityloxy)-6-methoxypyridin-2-yl)amino)benzonitrile

: 1580001-68-8
4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane; sodium iodide / acetonitrile / Reflux

2: N-iodo-succinimide; acetic acid; trifluoroacetic acid / 20 °C

With N-iodo-succinimide; chloro-trimethyl-silane; acetic acid; trifluoroacetic acid; sodium iodide; In acetonitrile;
DOI:10.1016/j.bmc.2014.01.054