(S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:96864-22-1
Molecular Formula:C₃₀H₅₃NO₄S
Molecular Weight:523.821
Hs Code.:

Synonyms:(S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of (S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of (S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 11 articles about (S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96303-88-7
(-)-10-dicyclohexylsulfamoyl-D-isoborneol

: 96864-22-1
(S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AgCN / benzene / 4 h / Heating

2: 1.) CuI*P(Bu)3; 2.) Et₂O*BF₃ / 1.) -78 deg C, 30 min, Et₂O; 2.) Et₂O-THF (4:1) -78 to -40 deg C, 20 h

3: 1N NaOH / aq. ethanol / Heating

4: AgCN / benzene / 4 h / Heating

5: 1.) CuI*P(Bu)3; 2.) BF*Et₂O / 1.) -78 deg C, 30 min, Et₂O; 2.) Et₂O-THF (4:1) -78 to -40 deg C, 20 h

With sodium hydroxide; silver cyanide; CuI*P(n-Bu)3; BF*Et₂O; boron trifluoride diethyl etherate; In ethanol; benzene;
DOI:10.1002/hlca.19850680126

Reference yield:

: (R)-3,4-Dimethyl-pent-4-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 96864-22-1
(S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1N NaOH / aq. ethanol / Heating

2: AgCN / benzene / 4 h / Heating

3: 1.) CuI*P(Bu)3; 2.) Et₂O*BF₃ / 1.) -78 deg C, 30 min, Et₂O; 2.) Et₂O-THF (4:1) -78 to -40 deg C, 20 h

4: 1N NaOH / aq. ethanol / Heating

5: AgCN / benzene / 4 h / Heating

6: 1.) CuI*P(Bu)3; 2.) BF*Et₂O / 1.) -78 deg C, 30 min, Et₂O; 2.) Et₂O-THF (4:1) -78 to -40 deg C, 20 h

With sodium hydroxide; silver cyanide; CuI*P(n-Bu)3; BF*Et₂O; boron trifluoride diethyl etherate; In ethanol; benzene;
DOI:10.1002/hlca.19850680126

Reference yield:

: 96864-31-2
<(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl>propionate

: 96864-22-1
(S)-3-Methyl-heptanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / LDA / tetrahydrofuran / -78 °C

2: LiAlH₄ / diethyl ether / 0.5 h / 0 - 20 °C

3: AgCN / benzene / 4 h / Heating

4: 1.) CuI*P(Bu)3; 2.) BF*Et₂O / 1.) -78 deg C, 30 min, Et₂O; 2.) Et₂O-THF (4:1) -78 to -40 deg C, 20 h

With lithium aluminium tetrahydride; silver cyanide; CuI*P(n-Bu)3; BF*Et₂O; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1002/hlca.19850680126