(+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

Base Information

Chemical Name:(+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine
CAS No.:172467-42-4
Molecular Formula:C₁₈H₁₄ClNO₂S
Molecular Weight:343.834
Hs Code.:

Synonyms:(+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

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Chemical Property of (+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

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Technology Process of (+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

There total 3 articles about (+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 172467-37-7
8-chloro-4H-pyrrolo<2,1-c><1,4>benzothiazin-4-one

: 172467-42-4
(+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

Guidance literature:: In tetrahydrofuran; diethyl ether; for 30h; Ambient temperature;
DOI:10.1021/jm00022a005

Reference yield:

: 91166-79-9
bis(4-chloro-2-N-pyrrolylphenyl)disulfide

: 172467-42-4
(+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium borohydride / 1.) EtOH, reflux, 20 min, 2.) EtOH, RT, 1 h

2: 82 percent / anhyd. zinc chloride / various solvent(s) / 5 h / Heating

3: 61 percent / tetrahydrofuran; diethyl ether / 30 h / Ambient temperature

With sodium tetrahydroborate; zinc(II) chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm00022a005

Reference yield:

: 172467-39-9
N-<5'-chloro-2'-<(ethoxycarbonyl)thio>phenyl>pyrrole

: 172467-42-4
(+/-)-8-chloro-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / anhyd. zinc chloride / various solvent(s) / 5 h / Heating

2: 61 percent / tetrahydrofuran; diethyl ether / 30 h / Ambient temperature

With zinc(II) chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm00022a005