(4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate

Base Information

Chemical Name:(4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate
CAS No.:1371609-09-4
Molecular Formula:C₁₄H₁₃ClN₂O₄
Molecular Weight:308.721
Hs Code.:

Synonyms:(4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate

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Chemical Property of (4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate

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Technology Process of (4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate

There total 1 articles about (4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1182366-72-8
(2R,3R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid

: 1371609-09-4
(4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / diethyl ether

1.2: 0.5 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C

With N-ethyl-N,N-diisopropylamine; potassium hydroxide; In diethyl ether; dichloromethane;

Reference yield: 80.0%

: 1371609-09-4
(4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate

: 1371609-10-7
2-chloro-4-((4S,5R)-4-(hydroxymethyl)-5-methyl-2-oxooxazolidin-3-yl)-3-methylbenzonitrile

Guidance literature:: With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 2h;

Reference yield:

: 1371609-09-4
(4R,5R)-methyl 3-(3-chloro-4-cyano-2-methylphenyl)-5-methyl-2-oxooxazolidine-4-carboxylate

: 1371609-11-8
C₁₃H₁₁ClN₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; sodium tetrahydroborate / 2 h / 0 - 20 °C

2: Dess-Martin periodane / acetonitrile / 0.5 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; Dess-Martin periodane; In acetonitrile;