4-amino-2,5-dimethoxybenzyl cyanide

Base Information

• Chemical Name: 4-amino-2,5-dimethoxybenzyl cyanide
• CAS No.: 168699-65-8
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• Mol file: 168699-65-8.mol

Synonyms:4-amino-2,5-dimethoxybenzyl cyanide

Chemical Property of 4-amino-2,5-dimethoxybenzyl cyanide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-amino-2,5-dimethoxybenzyl cyanide

There total 1 articles about 4-amino-2,5-dimethoxybenzyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2,5-Dimethoxy-4-nitro-phenyl)-acetonitrile (132370-32-2) → 4-amino-2,5-dimethoxybenzyl cyanide (168699-65-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 5h; under 2327.2 Torr;

DOI:10.1021/jm00020a024

Reference yield: 52.0%

4-amino-2,5-dimethoxybenzyl cyanide (168699-65-8) → 1-(4-amino-2,5-dimethoxyphenyl)-2-ethylamine

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 36h; under 2585.7 Torr;

DOI:10.1021/jm00020a024

Reference yield:

4-amino-2,5-dimethoxybenzyl cyanide (168699-65-8) → 1-(4-amino-2,5-dihydroxyphenyl)-2-ethylamine dihydrobromide

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / conc. HCl, H₂ / 10percent Pd/C / ethanol / 36 h / 2585.7 Torr

2: 72 percent / aq. HBr / 12 h / 90 - 95 °C

With hydrogenchloride; hydrogen bromide; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00020a024

upstream raw materials:

(2,5-Dimethoxy-4-nitro-phenyl)-acetonitrile