Technology Process of 4-amino-N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-2-methoxybenzamide
There total 8 articles about 4-amino-N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-2-methoxybenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3 h / 80 °C
2: concd. H2SO4 / 1 h / 150 °C
3: 1.) triethylamine, ethyl chloroformate / 1.) CHCl3, -10 deg C, 1 h, 2.)a) from -10 deg C to -5 deg C, 1 h, b) RT
With
sulfuric acid; chloroformic acid ethyl ester; triethylamine;
DOI:10.1021/jm00167a020
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 83 percent / dimethylformamide / 5 h / Heating
2: 88 percent / 85percent hydrazine monohydrate / ethanol / 0.5 h / Heating
3: 1.) triethylamine, ethyl chloroformate / 1.) CHCl3, -10 deg C, 1 h, 2.)a) from -10 deg C to -5 deg C, 1 h, b) RT
With
chloroformic acid ethyl ester; hydrazine hydrate; triethylamine;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a020
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) H2, acetic acid / 1.) Raney nickel / 1.) 95 percent EtOH, RT, 2.) CHCl3, RT, 2 h
2: 100 percent / 10percent HCl / 4 h / Heating
3: 1.) triethylamine, ethyl chloroformate / 1.) CHCl3, -10 deg C, 1 h, 2.)a) from -10 deg C to -5 deg C, 1 h, b) RT
With
hydrogenchloride; hydrogen; chloroformic acid ethyl ester; acetic acid; triethylamine;
nickel;
DOI:10.1021/jm00167a020
