(S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one
CAS No.:1558057-40-1
Molecular Formula:C₂₃H₂₂FNO₄
Molecular Weight:395.43
Hs Code.:

Synonyms:(S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

There total 5 articles about (S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₁₆O₃

: 1558057-40-1
(S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium chloride / tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

2: triethylamine; magnesium chloride / ethyl acetate / 72 h / 25 °C / Inert atmosphere

3: trifluoroacetic acid / methanol / 1.5 h / Inert atmosphere

With triethylamine; trifluoroacetic acid; lithium chloride; magnesium chloride; In tetrahydrofuran; methanol; ethyl acetate; 2: |Aldol Condensation;
DOI:10.1021/jm4017224

Reference yield:

: C₂₆H₃₀FNO₄Si

: 1558057-40-1
(S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

Guidance literature:: With trifluoroacetic acid; In methanol; for 1.5h; Inert atmosphere;
DOI:10.1021/jm4017224

Reference yield:

: 456-48-4
3-Fluorobenzaldehyde

: 1558057-40-1
(S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; magnesium chloride / ethyl acetate / 72 h / 25 °C / Inert atmosphere

2: trifluoroacetic acid / methanol / 1.5 h / Inert atmosphere

With triethylamine; trifluoroacetic acid; magnesium chloride; In methanol; ethyl acetate; 1: |Aldol Condensation;
DOI:10.1021/jm4017224