2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole

Base Information

Chemical Name:2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole
CAS No.:1376604-24-8
Molecular Formula:C₂₂H₁₇N₃O
Molecular Weight:339.396
Hs Code.:

Synonyms:2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole

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Chemical Property of 2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole

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Technology Process of 2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole

There total 13 articles about 2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1376604-23-7
2-(2-(3,5-diphenylpyridazin-4-yl)oxazol-4-yl)propan-2-ol

: 1376604-24-8
2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 2h; Reflux;

Reference yield:

: methyl 2-(3,5-diphenylpyridazin-4-yl)oxazole-4-carboxylate

: 1376604-24-8
2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / -40 - 20 °C

2: toluene-4-sulfonic acid / toluene / 2 h / Reflux

With toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

Reference yield:

: 1258614-99-1
methyl 3-chloro-5-phenylpyridazine-4-carboxylate

: 1376604-24-8
2-(3,5-diphenylpyridazin-4-yl)-4-(prop-1-en-2-yl)oxazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 12 h / 100 °C / Inert atmosphere

2.1: potassium hydroxide; water / methanol / 12 h / 100 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 20 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -76 °C

4.2: -78 - 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; Bromotrichloromethane / dichloromethane / 3 h / 0 °C

6.1: tetrahydrofuran / 1 h / -40 - 20 °C

7.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Bromotrichloromethane; diethylamino-sulfur trifluoride; water; sodium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;