(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid

Base Information

Chemical Name:(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid
CAS No.:1073544-41-8
Molecular Formula:C₃₃H₃₃FO₄
Molecular Weight:512.621
Hs Code.:

Synonyms:(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid

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Chemical Property of (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid

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Technology Process of (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid

There total 6 articles about (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1073546-94-7
ethyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoate

: 1073544-41-8
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid

Guidance literature:: ethyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 23 ℃; for 21h;

With hydrogenchloride; water; pH=1;

Reference yield:

: 14034-08-3
methyl 3-bromo-4-(tert-butyl)benzoate

: 1073544-41-8
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3.1: thionyl chloride / dichloromethane / 16 h / 23 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 23 °C

5.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 21 h / 23 °C

5.2: pH 1

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ethanol; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 406482-19-7
2-fluoro-5-methoxyphenylboronic acid

: 1073544-41-8
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3.1: thionyl chloride / dichloromethane / 16 h / 23 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 23 °C

5.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 21 h / 23 °C

5.2: pH 1

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ethanol; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;