C₂₃H₂₂ClN₅O

Base Information

• Chemical Name: C₂₃H₂₂ClN₅O
• CAS No.: 481048-69-5
• Molecular Formula: C₂₃H₂₂ClN₅O
• Molecular Weight: 419.914
• Mol file: 481048-69-5.mol

Synonyms:C₂₃H₂₂ClN₅O

Chemical Property of C₂₃H₂₂ClN₅O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₂ClN₅O

There total 6 articles about C₂₃H₂₂ClN₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

C17H11ClN2O2 (481049-35-8) + N-cyclopentyl-N'-guanidine hydrochloride → C23H22ClN5O (481048-69-5)

Guidance literature:

With potassium carbonate; In ethanol; at 80 ℃; for 12h;

DOI:10.1016/j.bmcl.2007.02.079

Reference yield:

C14H11ClN2O (168837-40-9) → C23H22ClN5O (481048-69-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / POCl₃ / 12 h / 20 °C

2: tetrahydrofuran / 2 h / -78 - 0 °C

3: MnO₂ / CH₂Cl₂ / 1 h

4: 50 percent / K₂CO₃ / ethanol / 12 h / 80 °C

With manganese(IV) oxide; potassium carbonate; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; 1: Vilsmeier-Haack reaction;

DOI:10.1016/j.bmcl.2007.02.079

Reference yield:

C15H11ClN2O2 (481049-34-7) → C23H22ClN5O (481048-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / -78 - 0 °C

2: MnO₂ / CH₂Cl₂ / 1 h

3: 50 percent / K₂CO₃ / ethanol / 12 h / 80 °C

With manganese(IV) oxide; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2007.02.079

upstream raw materials:

C₁₇H₁₁ClN₂O₂

C₁₄H₁₁ClN₂O

C₁₅H₁₁ClN₂O₂

2-amino-3-chloropyridine

Downstream raw materials:

C₂₈H₃₂N₆O

C₂₇H₃₀N₆O

Refernces