2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate

Base Information

Chemical Name:2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate
CAS No.:1595289-66-9
Molecular Formula:C₂HF₃O₂*C₁₈H₂₀N₆O₂
Molecular Weight:466.42
Hs Code.:

Synonyms:2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate

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Chemical Property of 2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate

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Technology Process of 2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate

There total 4 articles about 2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1595291-22-7
tert-butyl 4-((2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)amino)-1H-pyrazole-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1595289-66-9
2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 75726-96-4
2-bromo-N-isopropylacetamide

: 1595289-66-9
2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-tert-butyl dicarbonate; sodium carbonate / water; ethanol / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

3: dichloromethane / 5 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-tert-butyl dicarbonate; sodium carbonate; potassium carbonate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1595291-18-1
2-chloro-N-(1H-pyrazol-4-yl)pyrimidin-4-amine

: 1595289-66-9
2-(3-(4-((1H-pyrazol-4-yl)amino)pyrimidin-2-yl)phenoxy)-N-isopropylacetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dmap / dichloromethane / 3 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-tert-butyl dicarbonate; sodium carbonate / water; ethanol / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

3: dichloromethane / 5 h / 20 °C

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-tert-butyl dicarbonate; sodium carbonate; triethylamine; In ethanol; dichloromethane; water;