2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

Base Information

Chemical Name:2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid
CAS No.:1334675-76-1
Molecular Formula:C₂₂H₂₃F₂N₅O₃Si
Molecular Weight:471.539
Hs Code.:

Synonyms:2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

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Chemical Property of 2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

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Technology Process of 2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

There total 10 articles about 2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1334675-76-1
2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran

2.2: pH 4

3.1: Jones reagent / water; acetone / 0.25 h

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

4.2: 0 - 20 °C

5.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h / 80 °C / pressure tube; Inert atmosphere

6.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 1.25 h

With sodium chlorite; potassium dihydrogenphosphate; copper(l) iodide; Jones reagent; aminosulfonic acid; water; sodium hydride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 193353-34-3
2,5-difurorboronic acid

: 1334675-76-1
2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) chloride / methanol / 3 h / 60 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / Cooling with ice

2.2: 1.5 h

3.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h / 80 °C / pressure tube; Inert atmosphere

4.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 1.25 h

With sodium chlorite; potassium dihydrogenphosphate; copper(l) iodide; aminosulfonic acid; isopropylmagnesium chloride; copper(l) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1334674-87-1
(2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1334675-76-1
2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / tetrahydrofuran

1.2: pH 4

2.1: Jones reagent / water; acetone / 0.25 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 0 - 20 °C

4.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h / 80 °C / pressure tube; Inert atmosphere

5.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 1.25 h

With sodium chlorite; potassium dihydrogenphosphate; copper(l) iodide; Jones reagent; aminosulfonic acid; water; sodium hydride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; mineral oil;