CEB-1370 free base

Base Information

Chemical Name:CEB-1370 free base
CAS No.:224563-83-1
Molecular Formula:C₂₃H₃₃NO₃
Molecular Weight:371.52
Hs Code.:
UNII:942789S5TT
Nikkaji Number:J1.402.110H
Wikidata:Q27271633
ChEMBL ID:CHEMBL415316

Synonyms:CEB-1370 free base;UNII-942789S5TT;942789S5TT;1-(3-(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)propyl)-3-hydroxy-2-methyl-4(1H)-pyridinone;4(1H)-Pyridinone, 1-(3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)propyl)-3-hydroxy-2-methyl-;224563-83-1;CHEMBL415316;SCHEMBL8121689;Q27271633;1-[3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propyl]-2-methyl-3-hydroxypyridine-4(1H)-one

Suppliers and Price of CEB-1370 free base

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of CEB-1370 free base

Chemical Property:

XLogP3:5.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:371.24604391
Heavy Atom Count:27
Complexity:582

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=O)C=CN1CCCC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C)O

Technology Process of CEB-1370 free base

There total 6 articles about CEB-1370 free base which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 224564-29-8
3-benzyloxy-1-(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl)-2-methyl-4(1H)-pyridinone

: 224563-83-1
1-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-propyl]-3-hydroxy-2-methyl-1H-pyridin-4-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 22h;
DOI:10.1021/jm990945v

Reference yield:

: 34249-71-3
3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanamide

: 224563-83-1
1-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-propyl]-3-hydroxy-2-methyl-1H-pyridin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / LiAlH₄ / diethyl ether / 5.5 h / Heating

2: 40 percent / NaOH / ethanol; H₂O / 4.5 h / Heating

3: 84 percent / H₂ / Pd/C / ethanol / 22 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol; water; 1: Reduction / 2: Condensation / 3: Hydrogenolysis;
DOI:10.1021/jm990945v

Reference yield:

: 20170-32-5,90804-34-5
4-hydroxy-3,5-di-tert-butylphenylpropionic acid

: 224563-83-1
1-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-propyl]-3-hydroxy-2-methyl-1H-pyridin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride; DMF / toluene; CH₂Cl₂ / 2 h / 20 °C

2: 28.6 g / NH₄OH / tetrahydrofuran / 0.25 h / 0 °C

3: 45 percent / LiAlH₄ / diethyl ether / 5.5 h / Heating

4: 40 percent / NaOH / ethanol; H₂O / 4.5 h / Heating

5: 84 percent / H₂ / Pd/C / ethanol / 22 h / 20 °C

With ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene; 1: Chlorination / 2: Acylation / 3: Reduction / 4: Condensation / 5: Hydrogenolysis;
DOI:10.1021/jm990945v