(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane

Base Information

Chemical Name:(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane
CAS No.:289889-53-8
Molecular Formula:C₂₃H₂₆F₃NO₅
Molecular Weight:453.458
Hs Code.:

Synonyms:(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane

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Technology Process of (+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane

There total 1 articles about (+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 15893-42-2
3-(4-methoxyphenyl)propionyl chloride

: 79315-43-8
(+/-)-N-[2-(2,5-dimethoxyphenyl)-1-methylethyl]-2,2,2-trifluoroacetamide

: 289889-53-8
(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -30 ℃; for 0.5h;
DOI:10.1021/jm9906062

Reference yield:

: 289889-53-8
(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane

: 1026133-26-5
N-(2-{2,5-dimethoxy-4-[3-(4-methoxy-phenyl)-propyl]-phenyl}-1-methyl-ethyl)-2,2,2-trifluoro-acetamide

Guidance literature:: With perchloric acid; hydrogen; acetic acid; palladium on activated charcoal; for 6h; under 3102.89 Torr;
DOI:10.1021/jm9906062

Reference yield:

: 289889-53-8
(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(3-(4-methoxy)phenylpropionyl)phenyl]-2-aminopropane

: 2-{2,5-dimethoxy-4-[3-(4-methoxy-phenyl)-propyl]-phenyl}-1-methyl-ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂; AcOH; 70 percent HClO₄ / 10 percent Pd/C / 6 h / 3102.89 Torr

2: 15 percent NaOH; MeOH / 2 h / Heating

With methanol; sodium hydroxide; perchloric acid; hydrogen; acetic acid; palladium on activated charcoal; 1: Reduction / 2: Hydrolysis;
DOI:10.1021/jm9906062