(S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid

Base Information

Chemical Name:(S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid
CAS No.:1449786-54-2
Molecular Formula:C₂₂H₂₈N₄O₄
Molecular Weight:412.489
Hs Code.:

Synonyms:(S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid

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Chemical Property of (S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid

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Technology Process of (S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid

There total 6 articles about (S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₆N₄O₆

: 1449786-54-2
(S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.07.024

Reference yield:

: 1449786-44-0
(S)-methyl 4-amino-3-(2-(tert-butoxycarbonylamino)-4-phenylbutanamido)benzoate

: 1449786-54-2
(S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / 1,4-dioxane; water / 4 h / 25 °C / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 25 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.024

Reference yield:

: 36692-49-6
Methyl 3,4-diaminobenzoate

: 1449786-54-2
(S)-2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 25 °C / Inert atmosphere

2: lithium hydroxide / 1,4-dioxane; water / 4 h / 25 °C / Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 25 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.024