7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione

Base Information

Chemical Name:7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione
CAS No.:620598-16-5
Molecular Formula:C₃₂H₃₂N₄O₅
Molecular Weight:552.63
Hs Code.:

Synonyms:7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione

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Chemical Property of 7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione

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Technology Process of 7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione

There total 14 articles about 7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 7-phenoxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-(3-methyl-1H-indole-1-carboxylic acid tert-butyl ester)-1'-methyl-imidazolidine-2',4'-dione 0.5 DMF complex

: 620598-16-5
7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; at 60 ℃; for 1h;

Reference yield: 100.0%

: 620598-14-3
7-phenoxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-(1-tert-butoxycarbonylindol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione

: 620598-16-5
7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; at 60 ℃; for 1h;
DOI:10.1016/j.bmc.2003.08.022

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 620598-16-5
7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione

Guidance literature:: Multi-step reaction with 6 steps

1: TEA; DMAP / CH₂Cl₂

2: NaBH₄ / ethanol

3: 73 percent / TEA / CH₂Cl₂ / 0.25 h / 0 °C

4: 76 percent / CsHCO₃ / dimethylformamide / 48 h / 20 °C

5: 100 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

6: 100 percent / ammonium formate / Pd/C / methanol / 1 h / 60 °C

With dmap; sodium tetrahydroborate; cesium bicarbonate; TEA; ammonium formate; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2003.08.022