methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

Base Information

Chemical Name:methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate
CAS No.:224631-28-1
Molecular Formula:C₁₉H₂₂N₂O₅S₂
Molecular Weight:422.526
Hs Code.:

methyl <S-(R*,S*)>-6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

Synonyms:methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

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Chemical Property of methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

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Technology Process of methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

There total 4 articles about methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 56827-86-2
cesium thioacetate

: 224631-27-0
methyl -6-<(2-bromo-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

: 224631-28-1
methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1021/jo981425v

Reference yield:

: 42990-55-6,35016-63-8,42990-49-8,16503-53-0
(S)-(alpha)-bromobenzenepropanoic acid

: 224631-28-1
methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / HOBt, CMC / CH₂Cl₂ / 4 h / Ambient temperature

2: 70 percent / dimethylformamide / 24 h / Ambient temperature

With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981425v

Reference yield:

: 189747-77-1
methyl (R)-6-<(tert-butoxycarbonyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

: 224631-28-1
methyl -6-<(2-acetylthio-1-oxo-3-phenylpropyl)amino>-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂ / 2 h / 0 °C

2: 54 percent / HOBt, CMC / CH₂Cl₂ / 4 h / Ambient temperature

3: 70 percent / dimethylformamide / 24 h / Ambient temperature

With benzotriazol-1-ol; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981425v