(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Base Information

Chemical Name:(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate
CAS No.:1315334-38-3
Molecular Formula:C₅₀H₆₆N₄O₈S₂Si
Molecular Weight:943.314
Hs Code.:

(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Synonyms:(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

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Chemical Property of (S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

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Technology Process of (S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

There total 7 articles about (S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1137735-74-0
(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

: 1315334-37-2
2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanoic acid

: 1315334-38-3
(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: 2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; at 0 ℃; for 0.166667h;

(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2011.02.024

Reference yield:

: 297165-32-3
methyl 2-(tert-butoxycarbonylaminomethyl)thiazole-4-carboxylate

: 1315334-38-3
(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 0 - 20 °C

1.2: pH 1 - 2

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: lithium hydroxide / tetrahydrofuran; water / 0 - 20 °C

3.2: pH 1 - 2

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 0.17 h / 0 °C

4.2: 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2011.02.024

Reference yield:

: C₅₁H₅₇NO₅SSi

: 1315334-38-3
(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-(2-(2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxamido)-2-methylpropanamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylamine / acetonitrile / 2 h

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 0.17 h / 0 °C

2.2: 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1016/j.bmc.2011.02.024