1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Base Information

Chemical Name:1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione
CAS No.:165260-38-8
Molecular Formula:C₂₅H₂₃F₃N₄O₉S
Molecular Weight:612.54
Hs Code.:

Synonyms:1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

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Chemical Property of 1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

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Technology Process of 1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

There total 8 articles about 1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)pyrrolo<2,3-d>pyrimidine-2,4,5-trione

: 165260-38-8
1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at -78 ℃; for 0.25h; Yield given;
DOI:10.1021/jo00121a027

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 165260-38-8
1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / LiH / dimethylformamide / 1.) 0 deg C, 5 min, 2.) 0.5 h

2: 99 percent / LiH / dimethylformamide / 1.) 0 deg C, 10 min, 2.) 0.5 h

3: 1.) aq. NaOH, 2.) NaHCO₃ / 1.) aq. EtOH, r.t., 0.5 h, 2.) reflux, 6 h

4: n-Pr₃N / 0.75 h / 100 °C

5: Na₂CO₃*H₂O / methanol / 1.) 90 deg C, 3 min, 2.) 90 to 10 deg C

6: 2,4,6-collidine / CH₂Cl₂ / 0.25 h / -78 °C

With 2,4,6-trimethyl-pyridine; tri-n-propylamine; sodium hydroxide; lithium hydride; sodium hydrogencarbonate; sodium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a027

Reference yield:

: 29968-78-3
2-(4-nitrophenyl)ethylamine monohydrochloride

: 165260-38-8
1-(Benzyloxy)methyl-3-(methoxymethyl)-7-(p-nitrophenethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / aq. NaOH / 2.) ether, 80 h

2: 1.) aq. NaOH, 2.) NaHCO₃ / 1.) aq. EtOH, r.t., 0.5 h, 2.) reflux, 6 h

3: n-Pr₃N / 0.75 h / 100 °C

4: Na₂CO₃*H₂O / methanol / 1.) 90 deg C, 3 min, 2.) 90 to 10 deg C

5: 2,4,6-collidine / CH₂Cl₂ / 0.25 h / -78 °C

With 2,4,6-trimethyl-pyridine; tri-n-propylamine; sodium hydroxide; sodium hydrogencarbonate; sodium carbonate; In methanol; dichloromethane;
DOI:10.1021/jo00121a027