2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene

Base Information

• Chemical Name: 2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene
• CAS No.: 194734-14-0
• Molecular Formula: C₁₈H₂₇BrN₂O₂
• Molecular Weight: 389.281

Synonyms:2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene

Chemical Property of 2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene

Chemical Property:

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Technology Process of 2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene

There total 2 articles about 2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

[2H3]acetyl chloride (19259-90-6) + (2-Bromo-5-tert-butyl-3-methylaminomethyl-benzyl)-methyl-amine (194734-13-9) → 2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene (194734-14-0)

Guidance literature:

With triethylamine; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(97)00354-2

Reference yield:

2-bromo-1,3-bis(bromomethyl)-5-tert-butylbenzene (96929-82-7) → 2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene (194734-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / tetrahydrofuran; H₂O / 4 h / Heating

2: 89 percent / Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

With triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/S0040-4020(97)00354-2

Reference yield: 72.0%

2,6-bis[methyl(acetyl-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene (194734-14-0) → 2,6-bis[methyl(ethyl-2,2,2-d3)aminomethyl]-4-(1,1-dimethylethyl)bromobenzene

Guidance literature:

With borane-THF; In tetrahydrofuran; 1.) 60 deg C, 10 h, 2.) room temp., 12 h;

DOI:10.1016/S0040-4020(97)00354-2

upstream raw materials:

[2H₃]acetyl chloride

(2-Bromo-5-tert-butyl-3-methylaminomethyl-benzyl)-methyl-amine

2-bromo-1,3-bis(bromomethyl)-5-tert-butylbenzene

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