Clopidol

Base Information

• Chemical Name: Clopidol
• CAS No.: 2971-90-6
• Deprecated CAS: 68821-99-8,11116-46-4
• Molecular Formula: C7H7Cl2NO
• Molecular Weight: 192.045
• Hs Code.: 29333990
• European Community (EC) Number: 221-008-2
• NSC Number: 758964,253479
• UNII: 8J763HFF5N
• DSSTox Substance ID: DTXSID8041793
• Nikkaji Number: J7.399G
• Wikipedia: Clopidol
• Wikidata: Q5135111
• NCI Thesaurus Code: C76417
• ChEMBL ID: CHEMBL446918
• Mol file: 2971-90-6.mol

Synonyms:3,5-Dichloro-2,6-dimethyl-4-pyridinol;Clopidol;Clopindol;Meticlorpindol

Chemical Property of Clopidol

Chemical Property:

• Appearance/Colour: White to light-brown, crystalline solid
• Vapor Pressure: 0.117mmHg at 25°C
• Melting Point: >320 °C
• Refractive Index: 1.578
• Boiling Point: 251.1 °C at 760 mmHg
• PKA: 5.50±0.33(Predicted)
• Flash Point: 105.6 °C
• PSA: 32.86000
• Density: 1.37 g/cm³
• LogP: 2.29850
• Storage Temp.: 0-6°C
• Solubility.: Aqueous Base (Slightly), Methanol (Slightly, Heated)
• Water Solubility.: 40mg/L(temperature not stated)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 190.9904692
• Heavy Atom Count: 11
• Complexity: 252

Purity/Quality:

99% ^*data from raw suppliers

Clopidol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Uses -> Animal Feed Additives
• Canonical SMILES: CC1=C(C(=O)C(=C(N1)C)Cl)Cl
• Description: The drug methylchlorpindol is used for the prevention of coccidiosis in poultry. Clopidol is a coccidiostat. It prevents mortality of chickens infected with the parasites E. tenella, E. necatrix, E. acervuline, E. mivati, E. brunetti, and E. maxima. It has antimalarial activity against P. berghei in mice and P. cynomologi in rhesus macaques. Clopidol is a potential contaminant in food poultry. Formulations containing clopidol have been used in the prevention of coccidiosis in chickens.
• Uses: GABA Cl channel agonist, antiparasitic An antibiotic used in veterinary medicine as a coccidiostat in poultry. Showed low order of acute and chronic toxicity in animals. An antiprotozoal agent.

Technology Process of Clopidol

There total 3 articles about Clopidol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

ethyl acetoacetate (141-97-9) → 3,5-Dichloro-2,6-dimethyl-4-pyridinol (2971-90-6,68821-99-8)

Guidance literature:

ethyl acetoacetate; at 30 ℃; for 5h;

With ammonium hydroxide; at 10 ℃; for 2h;

With chlorine; at 30 ℃; for 2h; Reagent/catalyst; Temperature;

Reference yield:

2,6-dimethylpyridin-4-ol (13603-44-6) → 3,5-Dichloro-2,6-dimethyl-4-pyridinol (2971-90-6,68821-99-8) + C7H8ClNO

Guidance literature:

With N-chloro-succinimide; In methanol; dichloromethane; at 20 ℃; Overall yield = 73 percent; Overall yield = 940 mg; Inert atmosphere;

Reference yield:

→ 3,5-Dichloro-2,6-dimethyl-4-pyridinol (2971-90-6,68821-99-8)

Guidance literature:

2,6-Dimethyl-4-pyridinol, NaOCl, NaOH;

upstream raw materials:

ethyl acetoacetate

2,6-dimethylpyridin-4-ol

Refernces

• 1、 -. "Preparation method of 2, 6-dimethyl-3, 5-dichloro-4-hydroxypyridine". Paragraph 0009; 0020; 0021. . Retrieved 2016/10/10.
• 2、 -. "Improvements in or relating to antiprotozoal agents". . . Retrieved 2008/06/13.