(2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate

Base Information

Chemical Name:(2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate
CAS No.:159380-98-0
Molecular Formula:C₁₇H₂₄N₄O₄S
Molecular Weight:380.468
Hs Code.:

Synonyms:(2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate

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Chemical Property of (2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate

Chemical Property:

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Technology Process of (2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate

There total 7 articles about (2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (R)-benzyl 2-((tert-butoxycarbonyl)amino)-3-((2-((methylsulfonyl)oxy)ethyl)thio) propanoate

: 159380-98-0
(2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 70 ℃; for 8h;
DOI:10.1016/j.bmc.2019.05.005

Reference yield:

: 159380-94-6
(2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfanyl)propanoate

: 159380-98-0
(2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 36 h / -25 °C

2: tetramethylguanidinium azide / CH₂Cl₂ / 40 h / Ambient temperature

With pyridine; tetramethylguanidinum azide; In dichloromethane;

Reference yield:

: 6367-98-2,19179-73-8
(-)-(2R)-2-amino-3-(2-hydroxyethylsulfanyl)propanoic acid

: 159380-98-0
(2R)-(-)-benzyl 3-(2-azidoethylsulfanyl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: tert-butyl alcohol, aq. NaOH / Ambient temperature

2: 1.) CsHCO₃ / 1.) MeOH, 2.) DMF, RT, 3 h

3: pyridine / 36 h / -25 °C

4: tetramethylguanidinium azide / CH₂Cl₂ / 40 h / Ambient temperature

With pyridine; sodium hydroxide; cesium bicarbonate; tetramethylguanidinum azide; tert-butyl alcohol; In dichloromethane;