2β,3α-dihydroxy-5α-androstan-17-one

Base Information

• Chemical Name: 2β,3α-dihydroxy-5α-androstan-17-one
• CAS No.: 83808-48-4
• Molecular Formula: C₁₉H₃₀O₃
• Molecular Weight: 306.445
• Mol file: 83808-48-4.mol

Synonyms:2β,3α-dihydroxy-5α-androstan-17-one

Chemical Property of 2β,3α-dihydroxy-5α-androstan-17-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2β,3α-dihydroxy-5α-androstan-17-one

There total 8 articles about 2β,3α-dihydroxy-5α-androstan-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

p-toluidine (106-49-0,12221-03-3) + 2α,3α-epoxy-5α-androstan-17-one (965-67-3,7676-05-3,13094-19-4) → 3α-hydroxy-2β-((4'-methyl-phenyl)-amino)-5α-androst-17-one + 2β,3α-dihydroxy-5α-androstan-17-one (83808-48-4)

Guidance literature:

With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 100 ℃; for 8h;

DOI:10.1016/j.steroids.2006.04.006

Reference yield: 80.0%

thiophenol (108-98-5) + 2β,3β-epoxy-5α-androstan-17-one (7676-05-3) → 2β-hydroxy-3α-phenylthioandrostan-17-one (1207375-01-6) + 2β,3α-dihydroxy-5α-androstan-17-one (83808-48-4)

Guidance literature:

With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 100 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1055/S-0029-1217031

Reference yield: 73.0%

4-nitro-aniline (100-01-6,104810-17-5) + 2α,3α-epoxy-5α-androstan-17-one (965-67-3,7676-05-3,13094-19-4) → 3α-hydroxy-2β-((4-nitro-phenyl)-amino)-5α-androst-17-one + 2β,3α-dihydroxy-5α-androstan-17-one (83808-48-4)

Guidance literature:

With lithium trifluoromethanesulfonate; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 100 ℃; for 24h;

DOI:10.1016/j.steroids.2006.04.006

upstream raw materials:

4-amino-phenol

2α,3α-epoxy-5α-androstan-17-one

p-toluidine

p-aminobenzophenone

Refernces

• 1、 Horvath, Anita,Skoda-Foeldes, Rita,Maho, Sandor,Berente, Zoltan,Kollar, Laszlo. "Facile ring opening of 2,3-epoxy-steroids with aromatic amines in ionic liquids". . p. 706 - 711. Retrieved 2007/10/03.