1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine

Base Information

• Chemical Name: 1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine
• CAS No.: 179557-27-8
• Molecular Formula: C₁₈H₂₂N₄O₂
• Molecular Weight: 326.398
• Mol file: 179557-27-8.mol

Synonyms:1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine

Chemical Property of 1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine

There total 2 articles about 1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + 1-benzyl-N-methylpiperidin-4-amine (7006-50-0) → 1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine (179557-27-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 120h; Ambient temperature;

DOI:10.1021/jm960158n

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine (179557-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / sodium cyanoborohydride, 4 Angstroem molecular sieves / methanol / 24 h / Ambient temperature

2: 95 percent / K₂CO₃ / acetonitrile / 120 h / Ambient temperature

With 4 A molecular sieve; sodium cyanoborohydride; potassium carbonate; In methanol; acetonitrile;

DOI:10.1021/jm960158n

Reference yield: 100.0%

1-benzyl-4-[N-methyl-N-(3-nitro-2-pyridinyl)amino]piperidine (179557-27-8) → 4--1-(phenylmethyl)piperidine (163276-82-2)

Guidance literature:

With hydrogenchloride; titanium(III) chloride; for 21h; Ambient temperature;

DOI:10.1021/jm960158n

upstream raw materials:

2-Chloro-3-nitropyridine

1-benzyl-N-methylpiperidin-4-amine

1-phenylmethyl-4-piperidone

Downstream raw materials:

4--1-(phenylmethyl)piperidine

1-benzyl-4-[N-methyl-N-(3-(1-methylcyclopropylamino)-2-pyridinyl)amino]piperidine

1-benzyl-4-[N-methyl-N-(3-tert-butylamino-2-pyridinyl)amino]piperidine

1-benzyl-4-[N-methyl-N-(3-(cyclopropylamino)-2-pyridinyl)amino]piperidine