N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

Base Information

Chemical Name:N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester
CAS No.:264921-62-2
Molecular Formula:C₄₃H₆₃N₅O₁₀
Molecular Weight:810.001
Hs Code.:

N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

Synonyms:N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

Suppliers and Price of N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

There total 9 articles about N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 264921-61-1
[1S-(1α,2α,3β)]-2-[(allyloxycarbonyl)amino]-1-[N-(tert-butoxycarbonyl)-L-leucine methyl ester]-2-carboxy-3-phenylcyclopropane

: {2-[2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-acetylamino}-acetic acid benzotriazol-1-yl ester

: 264921-62-2
N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/jo991288h

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 264921-62-2
N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 0.91 g / acetonitrile / 72 h / 20 °C

2: 85 percent / RuCl₃; NaIO₄; NaHCO₃ / acetonitrile; CHCl₃; H₂O / 0.5 h / 20 °C

3: Et₃N / acetone; H₂O / 1 h / 0 °C

4: NaN₃ / CH₂Cl₂; H₂O / 1 h / 0 °C

5: CH₂Cl₂; toluene

6: 82 mg / 12 h / Heating

7: 27 mg / Pd(PPh₃)4; Bu₃SnH / CH₂Cl₂ / 6 h / 20 °C

With ruthenium trichloride; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; tri-n-butyl-tin hydride; sodium hydrogencarbonate; triethylamine; In dichloromethane; chloroform; water; acetone; toluene; acetonitrile; 1: Condensation / 2: Oxidation / 3: Condensation / 4: Substitution / 5: Curtius rearrangement / 6: Addition / 7: Condensation;
DOI:10.1021/jo991288h

Reference yield:

: 62530-41-0
Boc-Tyr(O-t-Bu)-Glu-Gly-OH

: 264921-62-2
N-[1S-(1α,2α,3β)]-2-[N-(tert-butoxycarbonyl)-L-tyrosine-t-butyl ether-L-glycine-L-glycine]-3-phenylcyclopropane-1-N-(tert-butoxycarbonyl)-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / CH₂Cl₂ / 1 h / 20 °C

2: 27 mg / Pd(PPh₃)4; Bu₃SnH / CH₂Cl₂ / 6 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; In dichloromethane; 1: Esterification / 2: Condensation;
DOI:10.1021/jo991288h