2'-Methyl-tosufloxacin

Base Information

Chemical Name:2'-Methyl-tosufloxacin
CAS No.:114676-84-5
Molecular Formula:C20H17 F3 N4 O3
Molecular Weight:418.37
Hs Code.:
DSSTox Substance ID:DTXSID20875212
Mol file:114676-84-5.mol

Synonyms:2'-METHYL-TOSUFLOXACIN;SCHEMBL9043957;DTXSID20875212;7-(4-amino-2-methylpyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Suppliers and Price of 2'-Methyl-tosufloxacin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2'-Methyl-tosufloxacin

Chemical Property:

Boiling Point:611.7°Cat760mmHg
Flash Point:323.7°C
PSA：101.45000
Density:1.496g/cm³
LogP:3.19240
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:418.12527490
Heavy Atom Count:30
Complexity:738

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(CN1C2=C(C=C3C(=O)C(=CN(C3=N2)C4=C(C=C(C=C4)F)F)C(=O)O)F)N

Technology Process of 2'-Methyl-tosufloxacin

There total 15 articles about 2'-Methyl-tosufloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114676-69-6
(2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 114676-84-5
(2'S,4'S)-7-(4'-amino-2'-methylpyrrolidinyl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 12 steps

1: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature

2: 93 percent / lithium borohydride / tetrahydrofuran / 16 h

3: 94 percent / triethylamine / CH₂Cl₂ / 15 h

4: lithium triethylborohydride / tetrahydrofuran / 2 h

5: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h

6: 16.1 g / triethylamine / CH₂Cl₂ / 14 h

7: 43 percent / tetra-n-butylammonium azide / acetonitrile / 3 h / 65 °C

8: hydrogen / 10percent palladium on carbon / methanol / 1 h / 3040 Torr

9: triethylamine / pyridine / 19 h / Ambient temperature

10: trifluoroacetic acid / 0.25 h

11: 78 percent / triethylamine / pyridine / 336 h / 65 °C

12: 1.) aq. NaOH, 2.) aq. hydrochloric acid / 1.) THF, 65 deg C, 4 h, 2.) 110 deg C, 15 h

With 1H-imidazole; hydrogenchloride; sodium hydroxide; lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; tetrabutylammoniun azide; lithium triethylborohydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00403a020

Reference yield:

: 114676-59-4
(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride

: 114676-84-5
(2'S,4'S)-7-(4'-amino-2'-methylpyrrolidinyl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 13 steps

1: 90 percent / triethylamine / CH₂Cl₂ / 12 h

2: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature

3: 93 percent / lithium borohydride / tetrahydrofuran / 16 h

4: 94 percent / triethylamine / CH₂Cl₂ / 15 h

5: lithium triethylborohydride / tetrahydrofuran / 2 h

6: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h

7: 16.1 g / triethylamine / CH₂Cl₂ / 14 h

8: 43 percent / tetra-n-butylammonium azide / acetonitrile / 3 h / 65 °C

9: hydrogen / 10percent palladium on carbon / methanol / 1 h / 3040 Torr

10: triethylamine / pyridine / 19 h / Ambient temperature

11: trifluoroacetic acid / 0.25 h

12: 78 percent / triethylamine / pyridine / 336 h / 65 °C

13: 1.) aq. NaOH, 2.) aq. hydrochloric acid / 1.) THF, 65 deg C, 4 h, 2.) 110 deg C, 15 h

With 1H-imidazole; hydrogenchloride; sodium hydroxide; lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; tetrabutylammoniun azide; lithium triethylborohydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00403a020

Reference yield:

: 113451-51-7
(2S,4S)-4-azido-1-(tert-butoxycarbonyl)-2-methylpyrrolidine

: 114676-84-5
(2'S,4'S)-7-(4'-amino-2'-methylpyrrolidinyl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / 10percent palladium on carbon / methanol / 1 h / 3040 Torr

2: triethylamine / pyridine / 19 h / Ambient temperature

3: trifluoroacetic acid / 0.25 h

4: 78 percent / triethylamine / pyridine / 336 h / 65 °C

5: 1.) aq. NaOH, 2.) aq. hydrochloric acid / 1.) THF, 65 deg C, 4 h, 2.) 110 deg C, 15 h

With hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In pyridine; methanol;
DOI:10.1021/jm00403a020