3-(4-fluorophenyl)-2-{[4-(2-furoyl)-1-piperazinyl]methyl}-4(3H)-quinazolinone

Base Information

Chemical Name:3-(4-fluorophenyl)-2-{[4-(2-furoyl)-1-piperazinyl]methyl}-4(3H)-quinazolinone
CAS No.:708293-58-7
Molecular Formula:C₂₄H₂₁FN₄O₃
Molecular Weight:432.454
Hs Code.:
Mol file:708293-58-7.mol

Synonyms:3-(4-fluorophenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one

Suppliers and Price of 3-(4-fluorophenyl)-2-{[4-(2-furoyl)-1-piperazinyl]methyl}-4(3H)-quinazolinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(4-fluorophenyl)-2-{[4-(2-furoyl)-1-piperazinyl]methyl}-4(3H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(4-fluorophenyl)-2-{[4-(2-furoyl)-1-piperazinyl]methyl}-4(3H)-quinazolinone

There total 3 articles about 3-(4-fluorophenyl)-2-{[4-(2-furoyl)-1-piperazinyl]methyl}-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873208-55-0
2-(chloromethyl)-3-(4-fluorophenyl)quinazolin-4(3H)-one

: 40172-95-0
N-(furan-2-carbonyl)piperazine

: 708293-58-7
3-(4-fluorophenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one

Guidance literature:: 2-(chloromethyl)-3-(4-fluorophenyl)quinazolin-4(3H)-one; With potassium carbonate; In ethanol; acetonitrile; at 150 ℃; for 0.0833333h; Microwave irradiation;

N-(furan-2-carbonyl)piperazine; In ethanol; acetonitrile; at 150 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.07.043

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 708293-58-7
3-(4-fluorophenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 - 20 °C

2.1: trichlorophosphate / acetonitrile / 0.25 h / 150 °C / Microwave irradiation

3.1: potassium carbonate / ethanol; acetonitrile / 0.08 h / 150 °C / Microwave irradiation

3.2: 0.17 h / 150 °C / Microwave irradiation

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.07.043

Reference yield:

: 14422-49-2
2-chloroacetamidobenzoic acid

: 708293-58-7
3-(4-fluorophenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / acetonitrile / 0.25 h / 150 °C / Microwave irradiation

2.1: potassium carbonate / ethanol; acetonitrile / 0.08 h / 150 °C / Microwave irradiation

2.2: 0.17 h / 150 °C / Microwave irradiation

With potassium carbonate; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.07.043