Technology Process of 1-((2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
There total 1 articles about 1-((2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / ammonia gas / methanol / 48 h / 0 - 4 °C
2: 65 percent / imidazole / dimethylformamide / 2 h / 20 °C
3: DMAP / acetonitrile / 1 h / 20 °C
4: 0.502 g / 2,2'-azobisisobutyronitrile; tributyltin hydride / toluene / 2 h / Heating
5: TBAF / tetrahydrofuran / 1 h / 20 °C
With
1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; ammonia; tri-n-butyl-tin hydride;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo034263y
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran
2: sodium methylate / methanol
3: benzyl triethylammonium azide; iodine; 4-methylmorpholine N-oxide / tetrahydrofuran
4: dmap / tetrahydrofuran; 1-methyl-pyrrolidin-2-one
5: ammonium bisulphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane
With
1H-imidazole; dmap; ammonium bisulphate; benzyl triethylammonium azide; iodine; sodium methylate; 4-methylmorpholine N-oxide; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.03.021
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 70.33 h / 0 - 20 °C
2.1: sodium methylate / methanol / 5 h / 60 °C
2.2: pyridinium form DOWEX H+ / 0.08 h / 0 - 20 °C
3.1: 4-methyl-morpholine; sodium azide; N-benzyl-N,N,N-triethylammonium chloride; iodine / tetrahydrofuran; acetonitrile / 6 h / 0 - 20 °C
3.3: 0 - 5 °C
4.1: dipotassium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 19.5 h / 20 °C
4.2: 0.5 h / 20 °C
5.1: pyridine
With
4-methyl-morpholine; pyridine; 1H-imidazole; dipotassium hydrogenphosphate; sodium azide; N-benzyl-N,N,N-triethylammonium chloride; iodine; sodium methylate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
