7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Base Information

Chemical Name:7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
CAS No.:146449-27-6
Molecular Formula:C₁₄H₁₈N₄O₄S
Molecular Weight:338.387
Hs Code.:

Synonyms:7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Chemical Property of 7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Technology Process of 7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

There total 26 articles about 7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 146449-15-2
7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

: 146449-27-6
7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: With nitric acid; acetic acid; for 2.5h; Ambient temperature;
DOI:10.1248/cpb.40.2391

Reference yield:

: 502-49-8
cycloactanone

: 146449-27-6
7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 8 steps

1: NaH / benzene

2: H₂ / 5percent Pd/C / ethanol / 760 Torr

3: 94.5 percent / LiAlH₄ / tetrahydrofuran

4: 64.2 percent / PBr₃ / diethyl ether; diethyl ether / 16 h / Ambient temperature

5: dimethylsulfoxide

6: 16.7 percent / CF₃COOH

7: 35 percent / heptane / 2 h / 140 - 150 °C

8: 90 percent / fuming HNO₃, AcOH / 2.5 h / Ambient temperature

With lithium aluminium tetrahydride; hydrogen; nitric acid; phosphorus tribromide; sodium hydride; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; n-heptane; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.40.2391

Reference yield:

: 1903-26-0
cyclododecylideneacetic acid ethyl ester

: 146449-27-6
7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 5percent Pd/C / ethanol / 760 Torr

2: LiAlH₄ / tetrahydrofuran

3: PBr₃ / diethyl ether; diethyl ether / 16 h / Ambient temperature

4: dimethylsulfoxide

5: 16.7 percent / CF₃COOH

6: 35 percent / heptane / 2 h / 140 - 150 °C

7: 90 percent / fuming HNO₃, AcOH / 2.5 h / Ambient temperature

With lithium aluminium tetrahydride; hydrogen; nitric acid; phosphorus tribromide; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; n-heptane; dimethyl sulfoxide;
DOI:10.1248/cpb.40.2391