(1R,2R)-(+)-2-[4-(4-fluorophenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol

Base Information

Chemical Name:(1R,2R)-(+)-2-[4-(4-fluorophenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol
CAS No.:1235703-62-4
Molecular Formula:C₂₀H₂₁FN₂O
Molecular Weight:324.398
Hs Code.:

Synonyms:(1R,2R)-(+)-2-[4-(4-fluorophenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-(+)-2-[4-(4-fluorophenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol

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Technology Process of (1R,2R)-(+)-2-[4-(4-fluorophenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol

There total 2 articles about (1R,2R)-(+)-2-[4-(4-fluorophenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 573-57-9
1,4-dihydronaphthalene-1,4-epoxide

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1235703-62-4
(1R,2R)-(+)-2-[4-(4-fluorophenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol

Guidance literature:: With chloro(1,5-cyclooctadiene)rhodium(I) dimer; ammonium iodide; PPF-P(t-Bu)2; In tetrahydrofuran; at 80 ℃; for 5h; optical yield given as %ee;
DOI:10.1007/s10562-010-0383-3

Reference yield:

: 573-57-9
1,4-epoxy-1,4-dihydronaphthalene

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1235703-62-4
(1R,2R)-(+)-2-[4-(4-fluorophenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol

: (1S,2S)-2-[4-(4-fluoro-phenyl)piperazin-1-yl]-1,2-dihydronaphthalen-1-ol

Guidance literature:: With ammonium iodide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,1′-binaphthalene-2,2′-diylbis[bis(4-methylphenyl)phosphine]; In tetrahydrofuran; at 80 ℃; for 10h; Overall yield = 91 %; Overall yield = 101 mg; enantioselective reaction;
DOI:10.3390/molecules201219748